Hi, recently about 10% of our brightfield *.ndpi uploads using OMERO.insight-5.4.1-ice36-b75-win fail to render in OMERO.web 5.4.6-ice36-b87. You'll find a 2.6GB 06-T05322_1A_HEc.ndpi as an example of such a fail2show under https://volafile.org/r/pmbwqedm Cheers Konrad