[lm-announce] Job opportunity in Munich

[Calum Thomson]

Hi All,

Here are details of an OMX microscopy position in Munich.Anyone requiring further details of the OMX system,please contact Emma in the microscopy office (MSI 1.05F,ext 86414) or at e.m.j.king at dundee.ac.uk.



Postdoctoral Position at the Ludwig Maximilians University, Munich

The Department of Biology, Ludwig Maximilians University (LMU), Munich, Germany announces a new Post-Doctorate Position in the field of Super-Resolution Microscopy and Cell Biology. The position is initially for two years with a possible extension. 
Position Description
The group of Professor Heinrich Leonhardt has recently set up a DeltaVision OMX Super-Resolution Microscope and conducts many different projects in Cellular and Molecular Biology. In addition, the group is collaborating with other European scientist to apply this technology to a broad range of biological questions. The position includes two weeks of intensive training in Issaquah, WA (near Seattle, Washington, USA) working with new methods in Three Dimensional, Structured Illumination Microscopy (3D-SIM). The postdoctoral fellow will then locate to LMU and participate in technology development and/or application with the possibility to communicate and publish scientific results. 
Description of DeltaVision OMX
The OMX system was developed at the University of California, San Francisco in the laboratories of John Sedat, David Agard, and Mats Gustafsson. The system was designed to address both temporal and spatial resolution limitations that constrain most Cell Biology experiments. Applied Precision, Inc., under exclusive license from UCSF, has commercialized the technology as the DeltaVision OMX Super-Resolution Microscopy System. Ten systems have now been installed worldwide. The first of the production systems was installed at LMU in Munich and will be used for this project. A hallmark of this system is the ability to achieve spatial resolution of better than one-half of the diffraction limit both laterally and axially and to do so in multiple channels (up to four) well away from the cover glass of the microscope slide (Science, 320, 1332-6).
Description of the Leonhardt Laboratory
The Leonhardt Laboratory studies the role and regulation of DNA methyltransferases (Dnmts) and their interacting factors with a broad spectrum of methods including genetic, biochemical, cellular and biophysical approaches in vitro and in vivo, in embryonic stem cells and transgenic animals. Their long-term goal is to better understand epigenetic regulation and to apply epigenetic (re-) programming to cellular differentiation, tissue regeneration and cancer therapy.
Over the last years they have developed a number of tools for live cell imaging including markers to follow cell cycle progression and a method to measure DNA methyltransferase activity in single living cells. Recently, they have developed fluorescent nanobodies (chromobodies) that allow targeting and tracing antigens in living cells. They are also developing and using new methods for high throughput imaging and for super-resolution microscopy (nanoscopy).
See homepage (http://sci.bio.lmu.de/epigenetics) for additional information.
Qualifications
Applicants must have a Ph.D. in Cell Biology, Biochemistry, Biophysics, Molecular Biology, Genetics, or a related field. Significant experience with advanced microscopy methods (deconvolution, confocal, multiphoton, etc.) and computer controlled hardware are highly preferred. Fluency in English is required. 
Interested candidates should contact either Professor Heinrich Leonhardt (h.leonhardt at lmu.de, +49 (89) 2180-74232) or Paul Goodwin (pgoodwin at api.com, +425 657 1316). 


Cheers,

Calum.



Calum Thomson
Light Microscopy Facility
WTB/MSI/JBC Biocentre
College of Life Sciences
University of Dundee
Dundee
DD1 5EH

Tel. 01382 388755

The University of Dundee is a registered Scottish charity, No: SC015096