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    <div class="moz-cite-prefix">Hi Dan,<br>
      <br>
      I would also be interested in looking at your nd2 files.  I wrote
      the bf-tools scripts and while they have been working adequately
      for us here, I would definitely like to see about speeding them up
      when I have a bit of time.  Could you share them via Dropbox or
      Google Drive or whatever is easiest for you?<br>
      <br>
      Thanks,<br>
      Pramukta<br>
      <br>
      On 12/20/2012 01:56 PM, Daniel Dickinson wrote:<br>
    </div>
    <blockquote
cite="mid:7FD710B59252634EA7903167D26E48B2504681EF@BL2PRD0310MB349.namprd03.prod.outlook.com"
      type="cite">
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      Hi again Melissa, 
      <div><br>
      </div>
      <div>I forgot to mention that I also tried opening these images
        using the BioFormats Importer plugin in ImageJ, and import
        failed.  The Fiji status bar displays "Parsing Block
        'ImageMetadat' 0%" but seems to be hung up there, and the image
        never displays.  </div>
      <div><br>
      </div>
      <div>If you think it would help, I'd be happy to figure out how to
        get you one of the problematic nd2 files so that you can try to
        reproduce the problem. </div>
      <div><br>
      </div>
      <div>Best, </div>
      <div>Dan </div>
      <div><br>
      </div>
      <div><br>
      </div>
      <div>
        <div>
          <div>On Dec 20, 2012, at 12:42 PM, Melissa Linkert <<a
              moz-do-not-send="true"
              href="mailto:melissa@glencoesoftware.com">melissa@glencoesoftware.com</a>></div>
          <div> wrote:</div>
          <br class="Apple-interchange-newline">
          <blockquote type="cite">Hi Dan,<br>
            <br>
            <blockquote type="cite">I suspect I may have discovered a
              bug or memory leak in the LOCI MATLAB toolbox.  I'm using
              the bfopen.m script to read Nikon ND2 files in MATLAB
              R2011a on Mac OSX 10.8.  I'm able to read a 63MB ND2 file
              without any problem.  However, when I attempt to read a
              120MB file, the program crashes with an "out of memory"
              error (full text of the error message is below).  However,
              I don't believe this is an issue of not enough memory
              being available, because increasing the maximum java heap
              memory from 256MB to 2GB in the MATLAB settings had no
              effect on the problem.  Also, I am able to read the files
              successfully using a different script (bfread.m from
              <a moz-do-not-send="true"
                href="https://github.com/prakatmac/bf-tools/wiki/about">https://github.com/prakatmac/bf-tools/wiki/about</a>),
              though it is slower than bfopen.m.<br>
            </blockquote>
            <br>
            Based upon the error message, it looks like bfopen.m was
            using an older<br>
            version of Bio-Formats.  The Matlab scripts from here:<br>
            <br>
            <a moz-do-not-send="true"
              href="https://github.com/prakatmac/bf-tools">https://github.com/prakatmac/bf-tools</a><br>
            <br>
            will download the latest version of loci_tools.jar and place
            it in an<br>
            'ext' folder, so it's likely that you now have two copies of<br>
            loci_tools.jar (one that is an old version and one that is
            the latest<br>
            version).<br>
            <br>
            Could you please try updating the copy of loci_tools.jar
            that is in your<br>
            Matlab work folder?  bfUpgradeCheck.m should be able to do
            this, or you can<br>
            manually download loci_tools.jar from:<br>
            <br>
<a class="moz-txt-link-freetext" href="http://www.openmicroscopy.org/site/products/bio-formats/downloads">http://www.openmicroscopy.org/site/products/bio-formats/downloads</a><br>
            <br>
            The output of 'version = loci.formats.FormatTools.VERSION'
            should then<br>
            be "4.4.5" (if you downloaded the stable version) or
            "4.5.0-DEV" (if you<br>
            downloaded the trunk or daily build).<br>
            <br>
            Regards,<br>
            -Melissa<br>
            <br>
            On Thu, Dec 20, 2012 at 03:07:28PM +0000, Daniel Dickinson
            wrote:<br>
            <blockquote type="cite">Hi,<br>
              <br>
              I suspect I may have discovered a bug or memory leak in
              the LOCI MATLAB toolbox.  I'm using the bfopen.m script to
              read Nikon ND2 files in MATLAB R2011a on Mac OSX 10.8.
               I'm able to read a 63MB ND2 file without any problem.
               However, when I attempt to read a 120MB file, the program
              crashes with an "out of memory" error (full text of the
              error message is below).  However, I don't believe this is
              an issue of not enough memory being available, because
              increasing the maximum java heap memory from 256MB to 2GB
              in the MATLAB settings had no effect on the problem.
               Also, I am able to read the files successfully using a
              different script (bfread.m from
              <a class="moz-txt-link-freetext" href="https://github.com/prakatmac/bf-tools/wiki/about">https://github.com/prakatmac/bf-tools/wiki/about</a>), though
              it is slower than bfopen.m.<br>
              <br>
              Thanks for any suggestions.<br>
              -Dan Dickinson<br>
              <br>
              <br>
              <blockquote type="cite">
                <blockquote type="cite">imageCell=bfopen(['/Users/danieldickinson/Documents/Postdoc/Data/Exp139/139_mChCtrl
                  nd2/139_mChCtrl_002.nd2']);<br>
                </blockquote>
              </blockquote>
              ??? Java exception occurred:<br>
              java.lang.OutOfMemoryError: Java heap space<br>
              at
              loci.formats.in.NativeND2Reader.iterateIn(NativeND2Reader.java:1486)<br>
              at
              loci.formats.in.NativeND2Reader.iterateIn(NativeND2Reader.java:1515)<br>
              at
              loci.formats.in.NativeND2Reader.initFile(NativeND2Reader.java:403)<br>
              at loci.formats.FormatReader.setId(FormatReader.java:1178)<br>
              at
              loci.formats.DelegateReader.setId(DelegateReader.java:259)<br>
              at loci.formats.ImageReader.setId(ImageReader.java:727)<br>
              at
              loci.formats.ReaderWrapper.setId(ReaderWrapper.java:529)<br>
              at
              loci.formats.ChannelFiller.setId(ChannelFiller.java:263)<br>
              at
              loci.formats.ReaderWrapper.setId(ReaderWrapper.java:529)<br>
              at
              loci.formats.ChannelSeparator.setId(ChannelSeparator.java:274)<br>
              <br>
              Error in ==> bfGetReader at 57<br>
              r.setId(id);<br>
              Error in ==> bfopen at 92<br>
              r = bfGetReader(id, stitchFiles);<br>
              <br>
              <br>
              **/.*********************************************<br>
              Daniel J. Dickinson, Ph.D.<br>
              Postdoctoral fellow, Goldstein Lab<br>
              University of North Carolina<br>
              650-815-1923<br>
              <a class="moz-txt-link-abbreviated" href="mailto:ddickins@live.unc.edu">ddickins@live.unc.edu</a><a class="moz-txt-link-rfc2396E" href="mailto:ddickins@live.unc.edu"><mailto:ddickins@live.unc.edu></a><br>
              <br>
            </blockquote>
            <br>
            <blockquote type="cite">_______________________________________________<br>
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            </blockquote>
            <br>
            <br>
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          <div>
            <div style="font-size: 12px; ">***********************************************</div>
            <div style="font-size: 12px; ">Daniel J. Dickinson, Ph.D.</div>
            <div style="font-size: 12px; ">Postdoctoral fellow,
              Goldstein Lab</div>
            <div style="font-size: 12px; ">University of North Carolina</div>
            <div style="font-size: 12px; ">650-815-1923</div>
            <div style="font-size: 12px; "><a moz-do-not-send="true"
                href="mailto:ddickins@live.unc.edu">ddickins@live.unc.edu</a></div>
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